History[ edit ] The journal began publishing on 3 October as the Provincial Medical and Surgical Journal and quickly attracted the attention of physicians around the world through its publication of high-impact original research articles and unique case reports. Cover of the 1st issue of the Provincial Medical and Surgical Journal The first issue of the British Medical Journal was 16 pages long and contained three simple woodcut illustrations. The longest items were the editors' introductory editorial and a report of the Provincial Medical and Surgical Association's Eastern Branch.
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Abstract The last part of the 19th century was a period of great achievements in medicine and endocrinology. The thyroid gland evolved from being considered a rudimentary structure to an organ related to specific diseases.
The singular importance of iodine became acknowledged. Graves-Basedow's disease British medical journal cover letter described. Surgical treatment evolved with extraordinary speed. Theodor Kocher observed that the clinical picture in patients after total thyroidectomy was similar to the one seen in cretinism.
Inthe first case of hypothyroidism or myxedema was described. Less than 50 years later, effective treatment was introduced.
Another 50 years later, autoimmune thyroiditis was ascertained as the most frequent cause of hypothyroidism in areas with no iodine deficiency.
This paper gives a short survey of the history of hypothyroidism and its treatment. Introduction During the 50 years preceding World War I, medicine saw a wealth of new ideas and novel procedures, not in the least within the field of endocrinology.
Halban [ 11 ] and Knauer [ 12 ] performed important experiments demonstrating that chemical substances controlling menstruations were released from the ovary. Similarly, Reinke [ 13 ] and Bouin and Ancel [ 14 ] proposed that testis was a gland with internal secretion—studies that were the vanguard of an impressive number of investigations on the relationship between the pituitary and the gonads [ 15 ].
The first hormone was synthesized adrenaline or epinephrine by Jokichi Takamine — in [ 16 ]. What was probably the supreme feat of the epoch took place on January 16, when William Bayliss — and Ernest Henry Starling — for the first time UK witnessed the effect of a substance later to be identified as a hormone secretin [ 17 ].
There was virtually no endocrine organ that did not become object of intensive investigation.
It became clear that diseases of the thyroid gland affect a large number of patients. In this paper, we briefly review how knowledge of the classical thyroid disease, then myxedema, now hypothyroidism, evolved. Early Observations on Myxedema Ina potentially important paper was published by Thomas Blizard Curling —surgeon at the London Hospital [ 18 ].
She had no power of speech. Both died and autopsy was performed. No trace of the thyroid gland could be found. In countries where cretinism and bronchocele prevail, it was long supposed, that there was some connection between the defective condition of the brain, and the hypertrophy of the thyroid.
Pathologists have recently been inclined to view the coincidence of these two affections as accidental, or as having no direct relation. But the association between the clinical symptoms and the thyroid gland was not appreciated. The paper was overlooked and forgotten—not mentioned even in a British review [ 19 ].
Twenty years would pass till the publication of the next paper on this topic [ 20 ]. Curling and Fagge were among the very last physicians to use the medieval expression bronchocele for goiter. It is beyond human imagination how this paper can be constructed as the first description of myxedema.
In Ord from St. Thomas Hospital [ 22 ] published a paper in which he coined the term myxoedema and published the first photography of a patient Figure 1. Its normal structure was almost entirely wanting, being replaced by myxoedematous infiltration.
The absence of a thyroid gland in cases of cretinoid idiocy is certainly curious, goitre being very abundant in regions where cretinism is endemic. He made further reflections in another paper in [ 23 ]. First photo of a patient with myxedema.
In all these papers cretinism, cretin, and cretinous were the key words. None of the authors was aware of the fundamental causal importance of the thyroid gland. He had become aware of a peculiar postoperative course in one of his patients. This led him to call in for followup as many as possible of the patients on whom he had performed thyroid surgery at that time a phenomenal number.
He immediately saw how the course significantly differed between patients who had undergone partial and patients after total thyroidectomy.
He made the conclusion that the symptoms present in patients in whom he had removed the entire thyroid were unmistakably similar to those found in patients with cretinism.
Dawtrey Drewitt presented a patient with classical symptoms of hypothyroidism [ 24 ]. At the same meeting, the first case of painless thyroiditis in pregnancy was briefly described.BMJ Case Reports is an award winning journal that delivers a focused, peer-reviewed, valuable collection of cases in all disciplines so that healthcare professionals, researchers and others can easily find clinically important information on common and rare conditions.
This is the largest single collection of case reports online with more than. Nov 21, · Startups news from the, including the latest news, articles, quotes, blog posts, photos, video and more.
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Meetings are . Whether you are a researcher, historian or you simply want to know more about Britain's history, take this fantastic opportunity to search The British Newspaper Archive - a vast treasure trove of historical newspapers from your own home.
A cover letter can outline the importance of your article to the journal’s readers. Pitching your idea Before you commit time to writing you could consider contacting the relevant editor to discuss your submission.
The BCGS quarterly “The British Columbia Genealogist” – Table of Contents Index. This database has a list of article titles from the Table of Contents of all issues of “The British Columbia Genealogist” published by the BCGS since , when the Society was created.
Since , the main surnames mentioned in articles are included in this searchable index.